In their last seven games as double-digit favorites, Buffalo is 5-1-1 against the spread, so betting Kenny Pickett and the Steelers could be one of the riskier NFL picks and NFL bets. Buffalo is the largest favorite on the board according to the latest Week 5 NFL odds from Caesars Sportsbook, spotting the Steelers 14 points at home. The NFL has already seen 26 underdogs win outright through the first four weeks of the 2022 season, and going against the favorites has been a profitable NFL betting strategy whether you're playing the spread or the money line.
